The Greater Antilles (Spanish: Grandes Antillas or Antillas Mayores; French: Grandes Antilles; Haitian Creole: Gwo Zantiy; Jamaican Patois: Grieta hAntiliiz) is a grouping of the larger islands in the Caribbean Sea, including Cuba, Hispaniola, Puerto Rico, Jamaica, and the Cayman Islands. Six island states share the region of the Greater Antilles, with Haiti and the Dominican Republic sharing the island of Hispaniola. Together with the Lesser Antilles, they make up the Antilles.

While most of the Greater Antilles consists of independent countries, Puerto Rico is an unincorporated territory of the United States, while the Cayman Islands are a British Overseas Territory. The largest island by area is Cuba, which extends to the western end of the island group. Puerto Rico lies on the eastern end, and the island of Hispaniola, the largest island by population, is located in the middle. Jamaica lies to the south of Cuba, while the Cayman Islands are located to the west. The state of Florida is the closest point in the U.S mainland to the Greater Antilles, while the Florida Keys, though not part of the Greater Antilles, is an island group north of Cuba.